The 13th annual HHL Conference was held virtually during a global pandemic. The agenda focused on a different region of the world for each day, with Day 1 centering around Africa, Day 2 speaking from Asia, and the cornerstone of Day 3 being the Americas. Each day was tied together with the overarching theme of “Building Efficient Supply Chain Connections,” which was supported by three subthemes: sustainable local procurement, health supply chain capacity strengthening, and last-mile transportation. In addition to panel discussions and keynotes, the multifaceted program also included numerous presentations led by practitioners and thought leaders on current challenges and practices in health and humanitarian systems. The event highlighted the determination commitment of organizers, sponsors, speakers, and participants to share knowledge, research, and practical perspectives for positive impact in our global community.